Gating current harmonics. IV. Dynamic properties of secondary activation kinetics in sodium channel gating
نویسندگان
چکیده
منابع مشابه
Inactivation of the sodium channel. II. Gating current experiments
Gating current (Ig) has been studied in relation to inactivation of Na channels. No component of Ig has the time course of inactivation; apparently little or no charge movement is associated with this step. Inactivation nonetheless affects Ig by immobilizing about two-thirds of gating charge. Immobilization can be followed by measuring ON charge movement during a pulse and comparing it to OFF c...
متن کاملSodium channels in planar lipid bilayers. Channel gating kinetics of purified sodium channels modified by batrachotoxin
Single channel currents of sodium channels purified from rat brain and reconstituted into planar lipid bilayers were recorded. The kinetics of channel gating were investigated in the presence of batrachotoxin to eliminate inactivation and an analysis was conducted on membranes with a single active channel at any given time. Channel opening is favored by depolarization and is strongly voltage de...
متن کاملGating of the Bacterial Sodium Channel, NaChBac
The bacterial sodium channel, NaChBac, from Bacillus halodurans provides an excellent model to study structure-function relationships of voltage-gated ion channels. It can be expressed in mammalian cells for functional studies as well as in bacterial cultures as starting material for protein purification for fine biochemical and biophysical studies. Macroscopic functional properties of NaChBac ...
متن کاملStochastic description of sodium channel gating.
A stochastic model of the sodium channel is proposed. Transitions from the resting to the open state of the channel is described by the gamma distribution. The open state is temporary with an average open time T, and the channel proceeds to the inactivated state. The channel can be represented by two identical control molecules which undergo conformation transitions under changes of the electri...
متن کاملAggregated Markov Processes and Channel Gating Kinetics
A finite state Markov process is aggregated into several groups. Rather than observing the underlying Markov process. one is only able to observe the aggregated process. What can be learned about the underlying process from the aggregated one? Such questions arise in she study of gating mechanisms in ion channels in muscle and nerve cell membranes. We discuss some recent results and their impli...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Biophysical Journal
سال: 1987
ISSN: 0006-3495
DOI: 10.1016/s0006-3495(87)83339-8